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Ezurpimtrostat hydrochloride
CAS No. 1914148-73-4
Ezurpimtrostat hydrochloride( —— )
Catalog No. M35677 CAS No. 1914148-73-4
Ezurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally available palmitoyl protein thioesterase-1 inhibitor with antifibrotic, antiviral, and anticancer effects that blocks cancer cell proliferation by interacting with palmitoyl protein thioesterase to inhibit late autophagy and dose-dependently increase lysosomal accumulation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 225 | Get Quote |
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| 5MG | 353 | Get Quote |
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| 10MG | 550 | Get Quote |
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| 25MG | 1122 | Get Quote |
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| 50MG | 1923 | Get Quote |
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| 100MG | 2547 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameEzurpimtrostat hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionEzurpimtrostat hydrochloride (GNS561 hydrochloride) is an orally available palmitoyl protein thioesterase-1 inhibitor with antifibrotic, antiviral, and anticancer effects that blocks cancer cell proliferation by interacting with palmitoyl protein thioesterase to inhibit late autophagy and dose-dependently increase lysosomal accumulation.
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DescriptionEzurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetAntiviral
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RecptorAntiviral
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Research Area——
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Indication——
Chemical Information
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CAS Number1914148-73-4
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Formula Weight459.45
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Molecular FormulaC25H32Cl2N4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (18.13 mM; Ultrasonic (<60°C)
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SMILESCl.CC(C)(C)NC1CCN(CC1)c1cc(NCc2ccc(Cl)cc2)nc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1.
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